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AZOMICS

A biotechnology focussed company with a threefold mission:

1) Dramatic healthspan extension and rejuvenation biotechnology therapeutics: addressing the underlying diseases of aging (focussed on the 9 Hallmarks of Aging [Lopez-Otin]) with the objective of extending healthspan by over 20 years for most people; and

2) Cognition Maintenance & Optimisation: maintenance and optimisation of cognitive ability and mood over a lifespan - and possible cognitive enhancement - with the earliest and most accurate possible detection of neurodegeneration - ie up to 20 years before symptoms- with some work on treating and stopping and possibly curing brain cancer and glioblastomas; and

3) Cardiovascular issue prevention and reversal: the earliest possible and most accurate diagnosis of cardiovascular disease, prevention of issues, and reversal of atherosclerosis or substantial reduction in risk profiles

And using computers and Artificial Intelligence to enhance the above.

OMICS are the collective characterization and quantification of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms. Deep understanding of the OMICS will permit effective therapies to address the above mission

Genomics

Epigenomics

Methylomics

Transcriptomics

Proteomics

Metabolomics

Lipidomics

Connectomics

Channelomics

Nutrigenomics

Microbiomics

Physiomics

Phenomics

Agrinomics

Genomics

Genomics - for consumers

Genomics are the study of your genome, the 3 billion base pairs that make you, you. 4 letters in varying sequences of A, C, G, T are the blueprint of you. (Note that your mitochondria -the powerhouse of the cell- also have a genome -much much smaller- human mtDNA includes 16,569 base pairs and encodes 13 proteins, which can also be studied).

You can get this listing of your blueprint from various companies. Some leaders are:

1. 23andme: www.23andme.com/

=> this provides you with a readout of under 1% of your blueprint/ your genome. You can download

your file and upload it to many sites that will tell you more about your prediliction to certain

diseases or attributes. However your ancestry data might make interesting reading

2. Veritas: www.veritasgenetics.com/ Provides you with your full genome

3. Dante Labs: www.dantelabs.com/ €899 for whole genome & exome: 130X for the Whole Exome + 30X for Whole Genome

=> Find a genetic counsellor skilled in interpreting your genome,

They can tell you what it all might mean, but currently they only understand with some reliability what under 10% of your genome means, AND they cannot tell you if the genes are turned on or off...

Note: The sum of all coding regions in a genome is called the exome. In humans, this includes some 23,000 genes with approximately 50 million bases. With whole-exome sequencing (WES), all exons (protein-coding regions) can be analyzed. So it could be most worthwhile focusing the genetic testing on the analysis of the 1%–2% of the human genome where 85% of known pathogenic mutations are found.

Epigenomics

The epigenome is a multitude of chemical compounds that can tell the genome what to do. So reading your epigenome details how your blueprint ie your genes, are turned on or off, or expressed up or down. So you might have a gene for something unpleasant, but it is turned off, so not a problem.

If you want to work out which genes are turned on, or off, the best companies to do this are ones that can read the methylation or your genes.

In our opinion, some companies active here are:

1) Chronomics: www.chronomics.com/ This company focusses on reading your epigenome to predict your biological age ie are your aging faster than your chronological age?

2) Life Epigenetics: lifeegx.com/ But not for consumers ie companies only

For further explanations, see https://www.genome.gov/about-genomics/fact-sheets/Epigenomics-Fact-Sheet

Epigenomics

Methylomics

In the course of life, aging processes, environmental influences and lifestyle factors such as smoking or diet induce biochemical alterations to the DNA. Frequently, these lead to DNA methylation, a process in which methyl groups are added to particular DNA segments, without changing the DNA sequence.

DNA methylation is an epigenetic mechanism that occurs by the addition of a methyl (CH3) group to DNA, thereby often modifying the function of the genes and affecting gene expression. ... When a CpG island in the promoter region of a gene is methylated, expression of the gene is repressed (it is turned off)

So the previous section on the Epigenome is how the methylome is expressed.

Transcriptomics

Transcript profiling ("Transcriptomics") is a widely used technique that obtains information on the abundance of multiple mRNA transcripts within a biological sample simultaneously.

Transcriptomics

Proteomics

Proteomics is the entire set of proteins that the genome produces or is modified by an organism or system. Proteomics has enabled the identification of ever increasing numbers of proteins. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes

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